The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to
study and treat the central nervous system. This is due in part to the scarcity of targets known …

Today, adeno-associated virus (AAV)-based vectors are arguably the most promising in vivo
gene delivery vehicles for durable therapeutic gene expression. Advances in molecular …

Recombinant adeno-associated virus (rAAV) vectors are gene therapy delivery tools that
offer a promising platform for the treatment of neurodegenerative diseases. Keeping up with …

T cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy
aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates …

Trained immunity (TI) is the process wherein innate immune cells gain functional memory
upon exposure to specific ligands or pathogens, leading to augmented inflammatory …

Although adeno-associated virus 9 (AAV9) has been highly exploited as delivery platform for
gene-based therapies, its efficacy is hampered by low efficiency in crossing the adult blood …

The blood-brain barrier (BBB) presents a major challenge to delivering large molecules to
study and treat the central nervous system (CNS). This is due in part to the scarcity of …

This study explored the role of lymphocyte antigen 6 family member D (LY6D) in colon
cancer stem cells'(CCSCs) proliferation and invasion. LY6D was knocked down using …

Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and
facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage …

The term cancer immunoediting describes the dual role by which the immune system can
both suppress and promote tumour growth and is divided into three phases: elimination …