Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …

Autophagy is a conserved cellular mechanism that enables the degradation and recycling of
cellular organelles and proteins via the lysosomal pathway. In neurodevelopment and …

Human brain organoid models have emerged as a promising tool for studying human brain
development and function. These models preserve human genetics and recapitulate some …

Abstract Autism Spectrum Disorder (ASD) is caused by genetic, epigenetic, and
environmental factors. Mutations in the human FMR1 gene, encoding the Fragile X …

Emerging evidence indicates that arginine methylation promotes the stability of arginine-
glycine-rich (RGG) motif-containing RNA-binding proteins (RBPs) and regulates gene …

Transplantation of bone marrow mesenchymal stem cells (BMSCs) represents an
encouraging strategy for the repair of spinal cord injury (SCI), however, its effectiveness on …

The human genome has many short tandem repeats, yet the normal functions of these
repeats are unclear. The 5′ untranslated region (UTR) of the fragile X messenger …

Fragile X syndrome (FXS) is caused by epigenetic silencing of the Fmr1 gene, leading to the
deletion of the coding protein FMRP. FXS induces abnormal hippocampal autophagy and …

High-resolution, real-time imaging of RNA is essential for understanding the diverse,
dynamic behaviors of individual RNA molecules in single cells. However, single-molecule …

Fragile X syndrome (FXS) is caused by epigenetic silencing of the X-linked fragile X
messenger ribonucleoprotein 1 (FMR1) gene located on chromosome Xq27. 3, which leads …