Phage therapy—challenges, opportunities and future prospects

B Zalewska-Piątek - Pharmaceuticals, 2023 - mdpi.com
The increasing drug resistance of bacteria to commonly used antibiotics creates the need to
search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly …

Bacteriophage therapy against ESKAPE bacterial pathogens: Current status, strategies, challenges, and future scope

M Kulshrestha, M Tiwari, V Tiwari - Microbial Pathogenesis, 2023 - Elsevier
The ESKAPE pathogens are the primary threat due to their constant spread of drug
resistance worldwide. These pathogens are also regarded as opportunistic pathogens and …

Antibacterial silver nanoparticles: effects on bacterial nucleic acids

M Alavi, MR Hamblin - Cellular, Molecular and Biomedical …, 2023 - cmbr-journal.com
Various microorganisms are located on the human skin, mucous membrane and inside the
human body. Many of these microorganisms are beneficial and few are even essential …

Monitoring phage-induced lysis of gram-negatives in real time using a fluorescent DNA dye

JE Egido, C Toner-Bartelds, AR Costa, SJJ Brouns… - Scientific Reports, 2023 - nature.com
Bacteriophages (phages) are viruses that specifically attack bacteria. Their use as
therapeutics, which constitutes a promising alternative to antibiotics, heavily relies on …

Ciprofloxacin in combination with bacteriophage cocktails against multi-drug resistant Pseudomonas aeruginosa in ex vivo simulated endocardial vegetation models

A El Ghali, K Stamper, AJ Kunz Coyne… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa-associated infective endocarditis represents difficult-to-treat,
deep-seated infections. Phage-antibiotic combinations have shown to eradicate multi-drug …

Potentiation and Mechanism of Berberine as an Antibiotic Adjuvant Against Multidrug-Resistant Bacteria

H Zhou, W Wang, L Cai, T Yang - Infection and Drug Resistance, 2023 - Taylor & Francis
The growing global apprehension towards multi-drug resistant (MDR) bacteria necessitates
the development of innovative strategies to combat these infections. Berberine (BER), an …

The burden of survivors: how can phage infection impact non-infected bacteria?

AV Letarov, MA Letarova - International Journal of Molecular Sciences, 2023 - mdpi.com
The contemporary understanding of complex interactions in natural microbial communities
and the numerous mechanisms of bacterial communication challenge the classical concept …

Pharmacokinetic and Pharmacodynamic Obstacles for Phage Therapy From the Perspective of Clinical Practice

R Międzybrodzki, H Kasprzak… - Clinical Infectious …, 2023 - academic.oup.com
Bacteriophages present unique features that enable targeted killing of bacteria, including
strains resistant to many antibiotics. However, phage pharmacokinetics and …

Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation

SC Nang, YW Lin, AP Fabijan, RYK Chang… - Clinical Microbiology …, 2023 - Elsevier
Background The increasing emergence of antimicrobial resistance worldwide has led to
renewed interest in phage therapy. Unlike antibiotics, the lack of pharmacokinetics …

Pseudomonas aeruginosa Bacteriophages and Their Clinical Applications

E Alipour-Khezri, M Skurnik, G Zarrini - Viruses, 2024 - mdpi.com
Antimicrobial resistance poses a serious risk to contemporary healthcare since it reduces
the number of bacterial illnesses that may be treated with antibiotics, particularly for patients …