Complex regional pain syndrome: practical diagnostic and treatment guidelines

RN Harden, CS McCabe, A Goebel, M Massey… - Pain …, 2022 - academic.oup.com
There have been some modest recent advancements in the research of Complex Regional
Pain Syndrome, yet the amount and quality of the work in this complicated multifactorial …

Complex regional pain syndrome—phenotypic characteristics and potential biomarkers

F Birklein, SK Ajit, A Goebel, RSGM Perez… - Nature Reviews …, 2018 - nature.com
Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single
limb, often following an injury. The underlying pathophysiology seems to be complex and …

Dietary interventions for treatment of chronic pain: oxidative stress and inflammation

AS Kaushik, LJ Strath, RE Sorge - Pain and Therapy, 2020 - Springer
Chronic pain is highly prevalent in the United States, impacting 28.4% of the adult
population, or 69.6 million people, as of 2016. Chronic pain is often associated with anxiety …

Autoinflammatory and autoimmune contributions to complex regional pain syndrome

J David Clark, VL Tawfik, M Tajerian… - Molecular …, 2018 - journals.sagepub.com
Complex regional pain syndrome (CRPS) is a highly enigmatic syndrome typically
developing after injury or surgery to a limb. Severe pain and disability are common among …

Oxidative stress is associated with characteristic features of the dysfunctional chronic pain phenotype

S Bruehl, G Milne, J Schildcrout, Y Shi, S Anderson… - Pain, 2022 - journals.lww.com
The dysfunctional chronic pain (Dysfunctional CP) phenotype is an empirically identifiable
CP subtype with unclear pathophysiological mechanisms that cuts across specific medical …

[HTML][HTML] Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome

TZ Guo, T Wei, TT Huang, WS Kingery, JD Clark - The Journal of Pain, 2018 - Elsevier
Clinical evidence suggests that vitamin C (Vit C) may protect against the development of
complex regional pain syndrome (CRPS) after fracture or surgery. Tibia fracture followed by …

A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients

KC Hung, MH Chiang, SC Wu, YJ Chang, CN Ho… - Scientific Reports, 2021 - nature.com
This meta-analysis aimed at investigating the impact of oral vitamin C supplementation on
the post-procedural recovery of orthopedic patients, including functional outcomes and …

Alpha-lipoic acid reduces nociception by reducing oxidative stress and neuroinflammation in a model of complex regional pain syndrome type I in mice

P Rodrigues, GB Cassanego, DS Peres… - Behavioural Brain …, 2024 - Elsevier
Complex regional pain syndrome type I (CRPS-I) is a disabling pain condition without
adequate treatment. Chronic post-ischemia pain injury (CPIP) is a model of CRPS-I that …

Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty

S Bruehl, G Milne, J Schildcrout, Y Shi, S Anderson… - Pain, 2023 - journals.lww.com
Total knee arthroplasty (TKA) is effective for pain reduction in most patients, but 15% or more
report unsatisfactory long-term pain outcomes. We tested whether oxidative stress (OS) …

Molecular signature of complex regional pain syndrome (CRPS) and its analysis

S König, T Schlereth, F Birklein - Expert Review of Proteomics, 2017 - Taylor & Francis
ABSTRACT Introduction: Complex Regional Pain Syndrome (CRPS) is a rare, but often
disabling pain disease. Biomarkers are lacking, but several inflammatory substances have …