Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

The thrombospondin family comprises of five multifunctional glycoproteins, whose best-
studied member is thrombospondin 1 (TSP1). This matricellular protein is a potent …

Glioblastomas (GBMs) are highly aggressive, infiltrative, and heterogeneous brain tumors
driven by complex genetic alterations. The basic-helix-loop-helix (bHLH) transcription …

Abstract Syntaxin-6 (STX6), a protein of the syntaxin family, is located in the trans-Golgi
network and is involved in a variety of intracellular membrane transport events. STX6 is …

Abstract Thioredoxin reductase 1 (TXNRD1) is one of the major redox regulators in
mammalian cells, which has been reported to be involved in tumorigenesis. However, its …

Epigenetics describes chemical modifications of the genome that do not alter DNA
sequence but participate in the regulation of gene expression and cellular processes such …

Autophagy has been involved in protection of ischemia/reperfusion (I/R)-induced injury in
many tissues including the brain. The upstream stimulatory factor 2 (Usf2) was proposed as …

Autophagy, a highly conserved self-digestion process crucial for cellular homeostasis, is
triggered by various environmental signals, including nutrient scarcity. The regulation of …

Inflammation is an adaptive response to tissue injury, which is a critical process in order to
restore tissue functionality and homeostasis. The association between inflammation and …