Background Recent changes in nutrition and lifestyle have provoked an unprecedented
increase in the prevalence of obesity and metabolic disorders. Recognition of the adverse …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that
circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major …

Background—We have previously shown that systemic infusion of insulin-like growth factor-
1 (IGF-1) exerts anti-inflammatory and antioxidant effects and reduces atherosclerotic …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and
subintimal modified lipoprotein deposition progress to complex, advanced lesions that are …

Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-
1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of …

Objective: Smooth muscle cells and pericytes display remarkable plasticity during injury and
disease progression. Here, we tested the hypothesis that perivascular cells give rise to Klf4 …

Background and Purpose—Low insulin-like growth factor 1 (IGF-1) has been associated
with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet …

Cardiovascular (CV) diseases are the most common health problems worldwide, with a
permanent increase in incidence. Growing evidence underlines that insulin-like growth …