Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …

In 1981 I established kingdom Chromista, distinguished from Plantae because of its more
complex chloroplast-associated membrane topology and rigid tubular multipartite ciliary …

Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …

Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake
results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol …

Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …

Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are …

Highlights•The apicoplast critically participates in metabolism of disease-causing
apicomplexans.•T. gondii overcomes loss of apicoplast-resident pathways through uptake of …

Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast,
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …

Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …