[HTML][HTML] The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies
T Zhong, W Zhang, H Guo, X Pan, X Chen, Q He… - … Pharmaceutica Sinica B, 2022 - Elsevier
Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …
permeable channels, and those relevant transmembrane and intracellular TRP channels …
Danger-and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers …
An increasing number of studies show that the activation of the innate immune system and
inflammatory mechanisms play an important role in the pathogenesis of numerous diseases …
inflammatory mechanisms play an important role in the pathogenesis of numerous diseases …
TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis
In multiple sclerosis, an inflammatory disease of the central nervous system (CNS), axonal
and neuronal loss are major causes for irreversible neurological disability. However, which …
and neuronal loss are major causes for irreversible neurological disability. However, which …
Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?
An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …
TRPM channels in human diseases
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
[HTML][HTML] Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway
I Montorfano, A Becerra, R Cerro, C Echeverría… - Laboratory …, 2014 - Elsevier
During the pathogenesis of systemic inflammation, reactive oxygen species (ROS) circulate
in the bloodstream and interact with endothelial cells (ECs), increasing intracellular …
in the bloodstream and interact with endothelial cells (ECs), increasing intracellular …
Counteracting arsenic toxicity: curcumin to the rescue?
A Bahrami, T Sathyapalan, SA Moallem… - Journal of hazardous …, 2020 - Elsevier
Arsenicosis leads to various irreversible damages in several organs and is considered to be
a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between …
a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between …
[HTML][HTML] Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters
A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …
multifunctional transducing organ that mediates a plethora of cardiovascular processes. The …
Sur1-Trpm4 cation channel expression in human cerebral infarcts
The nonselective monovalent cation channel transient receptor potential melastatin 4
(Trpm4) is transcriptionally upregulated in neural and vascular cells in animal models of …
(Trpm4) is transcriptionally upregulated in neural and vascular cells in animal models of …
The TRPM 4 channel inhibitor 9‐phenanthrol
R Guinamard, T Hof… - British journal of …, 2014 - Wiley Online Library
The phenanthrene‐derivative 9‐phenanthrol is a recently identified inhibitor of the transient
receptor potential melastatin (TRPM) 4 channel, a Ca 2+‐activated non‐selective cation …
receptor potential melastatin (TRPM) 4 channel, a Ca 2+‐activated non‐selective cation …