Coumarin derivatives are naturally and synthetically derived compounds and are
considered one of the most versatile classes of heterocycles. Discovering, synthesizing, and …

Malaria, a prevalent fatal disease around the world is caused by Plasmodium sp. and is
transmitted by the bite of female Anopheles mosquito. It is leading cause of death in this …

In the pursuit of novel therapeutic agents, we present a comprehensive study on the design,
synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo [1 …

Cytoskeletal proteins are essential for parasite proliferation, growth, and transmission, and
therefore have the potential to serve as drug targets. 1–5 While microtubules and their …

Cytoskeletal structures of Apicomplexan parasites are important for parasite replication,
motility, invasion to the host cell and survival. Apicortin, an Apicomplexan specific protein …

We employed a comprehensive approach of target-based virtual high-throughput screening
to find potential hits from the ZINC database of natural compounds against cysteine …

A new strategy for synthesizing chirally enriched pyrazolylpyrimidinone-based glycohybrids
has been achieved, employing an annulation approach in ethanol without any additives or …

Amino pyrimidines are vital molecules that exhibit diverse biological activities and serve as
structural motifs in various pharmaceutical drugs. Four new series of triazole‐linked …

Molecular hybridization is an emerging strategy in medicinal chemistry for designing new
bioactive molecules that link pharmacophores covalently and shows synergistic enhanced …

Since the discovery of dicoumarol (a coumarin-based anticoagulant) in 1940, coumarins
have been found to possess a range of biological activities such as antimicrobial, anti …