Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory …

Like most modern molecular biology and natural product chemistry, understanding
cannabinoid pharmacology centers around molecular interactions, in this case, between the …

Cannabinoid-derived drugs are promising agents for the development of novel
neuroprotective strategies. Activation of neuronal CB1 cannabinoid receptors attenuates …

Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …

Cannabis sativa L. preparations have been used in medicine for millenia. However, concern
over the dangers of abuse led to the banning of the medicinal use of marijuana in most …

Lipid metabolism is of particular interest due to its high concentration in CNS. The
importance of lipids in cell signaling and tissue physiology is demonstrated by many CNS …

The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and
cannabis active components, is the most abundant G protein-coupled receptor in the …

Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1
cannabinoid receptors. These receptors are highly abundant in the basal ganglia and play a …

Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental
periods can result in adverse health outcomes later in life. Human cohort studies have …