The intestine serves as both our largest single barrier to the external environment and the
host of more immune cells than any other location in our bodies. Separating these potential …

Type I interferons (IFNs) are best known for their role in innate immunity, but they are also
involved in other functions including immunomodulation, restricting proliferation, cancer …

Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in
macrophages, but whether they have distinct functions remains unclear. We confirmed that …

Cancer cells frequently alter their lipids to grow and adapt to their environment,–. Despite
the critical functions of lipid metabolism in membrane physiology, signalling and energy …

Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …

Understanding how membrane nanoscale organization controls transmembrane receptors
signaling activity remains a challenge. We studied interferon-γ receptor (IFN-γR) signaling in …

Abstract Background & Aims Advanced colorectal carcinoma (CRC) is characterized by a
high frequency of primary immune evasion and refractoriness to immunotherapy. Given the …

Background/Aims We previously demonstrated that anthocyanin-rich bilberry extract (ARBE)
inhibits IFN-γ-induced signalling and downstream effects in human monocytic cells and …

Early views of autoimmune disease cast IFNγ as a prototypic pro-inflammatory factor. It is
now clear that IFNγ is capable of both pro-and anti-inflammatory activities with the functional …