Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of
members of the long-chain helical cytokine family. It is mainly produced by adipocytes in …

Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular
diseases. Leptin levels are directly associated with adipose tissue mass, while adiponectin …

Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is primarily
involved in the regulation of food intake and energy expenditure. Leptin receptors are …

Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on
multiple organ systems. In this review, we summarize major leptin signaling pathways …

The prevalence of obesity, especially among the young, is dramatically increasing in the
United States. Obesity is associated with accelerated atherosclerosis and increased rates of …

The development of vascular disease has its origins in an initial insult to the vessel wall by
biological or mechanical factors. The disruption of homeostatic mechanisms leads to …

The metabolic syndrome, which is very common in the general population, is defined by the
clustering of several classic cardiovascular risk factors, such as type 2 diabetes …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …

Background and purpose: Protection against ischaemia‐reperfusion (I/R) injury involves
PI3K‐Akt and p44/42 MAPK activation. Leptin which regulates appetite and energy balance …

Obesity is a major risk factor for cardiovascular diseases, but the mechanisms for increased
cardiovascular risk in obesity are still unclear. Inflammation and increased oxidative stress …