[HTML][HTML] Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

[HTML][HTML] Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

BCLA CLEAR–Contact lens technologies of the future

L Jones, A Hui, CM Phan, ML Read, D Azar… - Contact lens and …, 2021 - Elsevier
Contact lenses in the future will likely have functions other than correction of refractive error.
Lenses designed to control the development of myopia are already commercially available …

Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration

FA Maulvi, KH Shetty, DT Desai, DO Shah… - International journal of …, 2021 - Elsevier
The human eye is a complex organ with unique anatomy and physiology that restricts the
delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy …

[HTML][HTML] Chitosan-coated PLGA nanoparticles encapsulating triamcinolone acetonide as a potential candidate for sustained ocular drug delivery

M Dandamudi, P McLoughlin, G Behl, S Rani, L Coffey… - Pharmaceutics, 2021 - mdpi.com
The current treatment for the acquired retinal vasculopathies involves lifelong repeated
intravitreal injections of either anti-vascular endothelial growth factor (VEGF) therapy or …

Recent progress and strategies to develop antimicrobial contact lenses and lens cases for different types of microbial keratitis

SA Khan, CS Lee - Acta Biomaterialia, 2020 - Elsevier
Although contact lenses are widely used for vision correction, they are also the primary
cause of a number of ocular diseases such as microbial keratitis (MK), etc. and inflammatory …

[HTML][HTML] Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

AF Pereira-da-Mota, CM Phan, A Concheiro… - Journal of Controlled …, 2022 - Elsevier
Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms,
but the feasibility of medicated CL development is constrained by numerous scientific …

Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis

RB Singh, S Das, J Chodosh, N Sharma… - Progress in Retinal and …, 2022 - Elsevier
Bacterial keratitis continues to be one of the leading causes of corneal blindness in the
developed as well as the developing world, despite swift progress since the dawn of the …

Nanoparticle-laden contact lens for controlled release of vancomycin with enhanced antibiotic efficacy

WY Tong, WN Tan, MAK Azizi, CR Leong, IH El Azab… - Chemosphere, 2023 - Elsevier
Vancomycin is the last resort antibiotic for the treatment of severe bacterial keratitis. Its
clinical application is limited due to its hydrophilicity and high molecular weight. To …

Advances and challenges in the nanoparticles-laden contact lenses for ocular drug delivery

FA Maulvi, DT Desai, KH Shetty, DO Shah… - International journal of …, 2021 - Elsevier
The delivery of drugs that target ocular tissues is challenging due to the physiological
barriers of the eye like tear dilution, nasolacrimal drainage, blinking, tear turnover rate and …