Translesion and repair DNA polymerases: diverse structure and mechanism
W Yang, Y Gao - Annual review of biochemistry, 2018 - annualreviews.org
The number of DNA polymerases identified in each organism has mushroomed in the past
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …
DNA polymerase θ (POLQ), double-strand break repair, and cancer
DNA polymerase theta (pol θ) is encoded in the genomes of many eukaryotes, though not in
fungi. Pol θ is encoded by the POLQ gene in mammalian cells. The C-terminal third of the …
fungi. Pol θ is encoded by the POLQ gene in mammalian cells. The C-terminal third of the …
Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia
SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …
past the death of the founder animal in which the cancer initiated. We investigated the …
Telomerase mechanism of telomere synthesis
RA Wu, HE Upton, JM Vogan… - Annual review of …, 2017 - annualreviews.org
Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …
Eukaryotic DNA polymerases
R Jain, AK Aggarwal, O Rechkoblit - Current opinion in structural biology, 2018 - Elsevier
Highlights•Humans encode 16 bone-fide DNA polymerases.•Replicative DNA polymerases
are emerging as highly flexible and dynamic in their interactions.•Mutations in replicative …
are emerging as highly flexible and dynamic in their interactions.•Mutations in replicative …
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
MettL3-MettL14 methyltransferase complex has been studied widely for its role in RNA
adenine methylation. This complex is also recruited to UV-and X-ray exposed DNA …
adenine methylation. This complex is also recruited to UV-and X-ray exposed DNA …
Reclassification of family A DNA polymerases reveals novel functional subfamilies and distinctive structural features
Abstract Family A DNA polymerases (PolAs) form an important and well-studied class of
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
extant polymerases participating in DNA replication and repair. Nonetheless, despite the …
RETRACTED: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair
Cancers with hereditary defects in homologous recombination rely on DNA polymerase q
(pol q) for repair of DNA double-strand breaks. During end joining, pol q aligns …
(pol q) for repair of DNA double-strand breaks. During end joining, pol q aligns …
How DNA polymerases catalyse replication and repair with contrasting fidelity
DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …
Multifaceted nature of DNA polymerase θ
AA Kruchinin, AV Makarova - International Journal of Molecular Sciences, 2023 - mdpi.com
DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA
repair and damage tolerance, including double-strand break repair and DNA translesion …
repair and damage tolerance, including double-strand break repair and DNA translesion …