Purity independent subtyping of tumors (PurIST), a clinically robust, single-sample classifier for tumor subtyping in pancreatic cancer
Purpose: Molecular subtyping for pancreatic cancer has made substantial progress in recent
years, facilitating the optimization of existing therapeutic approaches to improve clinical …
years, facilitating the optimization of existing therapeutic approaches to improve clinical …
Consensus on molecular subtypes of high-grade serous ovarian carcinoma
Purpose: The majority of ovarian carcinomas are of high-grade serous histology, which is
associated with poor prognosis. Surgery and chemotherapy are the mainstay of treatment …
associated with poor prognosis. Surgery and chemotherapy are the mainstay of treatment …
The current staging and classification systems of breast cancer and their pitfalls: Is it possible to integrate the complexity of this neoplasm into a unified staging system …
FAC da Luz, BJ Araujo, RA de Araujo - Critical Reviews in Oncology …, 2022 - Elsevier
Breast cancer is one of the leading causes of cancer death in women worldwide due to its
variable aggressiveness and high propensity to develop distant metastases. The staging …
variable aggressiveness and high propensity to develop distant metastases. The staging …
[HTML][HTML] Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases
Bone metastases (BoM) are a significant cause of morbidity in patients with estrogen
receptor–positive (ER-positive) breast cancer; yet, characterizations of human specimens …
receptor–positive (ER-positive) breast cancer; yet, characterizations of human specimens …
Feature selection in clinical proteomics: with great power comes great reproducibility
Highlights•Null-hypothesis statistical testing is irreproducible because of P-value variability.•
Irreproducibility can be circumvented by boosting power.•Increasing sample size and …
Irreproducibility can be circumvented by boosting power.•Increasing sample size and …
TimiGP: Inferring cell-cell interactions and prognostic associations in the tumor immune microenvironment through gene pairs
Determining the prognostic association of different immune cell types in the tumor
microenvironment is critical for understanding cancer biology and developing new …
microenvironment is critical for understanding cancer biology and developing new …
Detecting prognostic biomarkers of breast cancer by regularized Cox proportional hazards models
Background The successful identification of breast cancer (BRCA) prognostic biomarkers is
essential for the strategic interference of BRCA patients. Recently, various methods have …
essential for the strategic interference of BRCA patients. Recently, various methods have …
Alternative empirical Bayes models for adjusting for batch effects in genomic studies
Background Combining genomic data sets from multiple studies is advantageous to
increase statistical power in studies where logistical considerations restrict sample size or …
increase statistical power in studies where logistical considerations restrict sample size or …
Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma
K Liu, Y Geng, L Wang, H Xu, M Zou, Y Li… - Molecular …, 2022 - Wiley Online Library
Resistance to gemcitabine is the main challenge of chemotherapy for pancreatic ductal
adenocarcinoma (PDAC). Hence, the development of a response signature to gemcitabine …
adenocarcinoma (PDAC). Hence, the development of a response signature to gemcitabine …
The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB
Y Okita, M Kimura, R Xie, C Chen, LTW Shen… - Science …, 2017 - science.org
Triple-negative breast cancer (TNBC) is particularly aggressive and difficult to treat. For
example, the transforming growth factor–β (TGF-β) pathway is implicated in TNBC …
example, the transforming growth factor–β (TGF-β) pathway is implicated in TNBC …