Simplicity is the ultimate sophistication—crosstalk of post-translational modifications on the rna polymerase ii
The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …
Coupling of integrin α5 to annexin A2 by flow drives endothelial activation
C Zhang, T Zhou, Z Chen, M Yan, B Li, H Lv… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerosis preferentially occurs at specific sites of the vasculature where
endothelial cells (ECs) are exposed to disturbed blood flow. Translocation of integrin α5 to …
endothelial cells (ECs) are exposed to disturbed blood flow. Translocation of integrin α5 to …
Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription
The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to
RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the …
RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the …
A combinatorial view of old and new RNA polymerase II modifications
DE Lyons, S McMahon, M Ott - Transcription, 2020 - Taylor & Francis
The production of mRNA is a dynamic process that is highly regulated by reversible post-
translational modifications of the C-terminal domain (CTD) of RNA polymerase II. The CTD is …
translational modifications of the C-terminal domain (CTD) of RNA polymerase II. The CTD is …
Thr4 phosphorylation on RNA Pol II occurs at early transcription regulating 3′-end processing
RNA polymerase II relies on a repetitive sequence domain (YSPTSPS) within its largest
subunit to orchestrate transcription. While phosphorylation on serine-2/serine-5 of the …
subunit to orchestrate transcription. While phosphorylation on serine-2/serine-5 of the …
Ssu72 dual-specific protein phosphatase: from gene to diseases
S Hwang, MH Kim, CW Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
More than 70% of eukaryotic proteins are regulated by phosphorylation. However, the
mechanism of dephosphorylation that counteracts phosphorylation is less studied …
mechanism of dephosphorylation that counteracts phosphorylation is less studied …
Evaluating spatiotemporal dynamics of phosphorylation of RNA polymerase II carboxy-terminal domain by ultraviolet photodissociation mass spectrometry
The critical role of site-specific phosphorylation in eukaryotic transcription has motivated
efforts to decipher the complex phosphorylation patterns exhibited by the carboxyl-terminal …
efforts to decipher the complex phosphorylation patterns exhibited by the carboxyl-terminal …
Collaborators or competitors: the communication between RNA polymerase II and the nucleosome during eukaryotic transcription
HA Hardtke, YJ Zhang - Critical Reviews in Biochemistry and …, 2024 - Taylor & Francis
Decades of scientific research have been devoted to unraveling the intricacies of eukaryotic
transcription since the groundbreaking discovery of eukaryotic RNA polymerases in the late …
transcription since the groundbreaking discovery of eukaryotic RNA polymerases in the late …
Structural motifs for CTD kinase specificity on RNA polymerase II during eukaryotic transcription
The phosphorylation states of RNA polymerase II coordinate the process of eukaryotic
transcription by recruitment of transcription regulators. The individual residues of the …
transcription by recruitment of transcription regulators. The individual residues of the …
What's all the phos about? Insights into the phosphorylation state of the RNA polymerase II C-terminal domain via mass spectrometry
RNA polymerase II (RNAP II) is one of the primary enzymes responsible for expressing
protein-encoding genes and some small nuclear RNAs. The enigmatic carboxy-terminal …
protein-encoding genes and some small nuclear RNAs. The enigmatic carboxy-terminal …