Rethinking mechanisms, diagnosis and management of endometriosis

C Chapron, L Marcellin, B Borghese… - Nature Reviews …, 2019 - nature.com
Endometriosis is a chronic inflammatory disease defined as the presence of endometrial
tissue outside the uterus, which causes pelvic pain and infertility. This disease should be …

Hormonal treatments for endometriosis: The endocrine background

S Vannuccini, S Clemenza, M Rossi… - Reviews in Endocrine and …, 2022 - Springer
Endometriosis is a benign uterine disorder characterized by menstrual pain and infertility,
deeply affecting women's health. It is a chronic disease and requires a long term …

[HTML][HTML] Dysmenorrhea and related disorders

M Bernardi, L Lazzeri, F Perelli, FM Reis… - …, 2017 - ncbi.nlm.nih.gov
Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is
also represented in most women as a primary form of disease. Pain associated with …

Endometriosis and medical therapy: from progestogens to progesterone resistance to GnRH antagonists: a review

J Donnez, MM Dolmans - Journal of Clinical Medicine, 2021 - mdpi.com
Background: The first objective of this review was to present, based on recent literature, the
most frequently applied medical options (oral contraceptive pills (OCPs) and progestogens) …

[HTML][HTML] Choosing the right surgical technique for deep endometriosis: shaving, disc excision, or bowel resection?

O Donnez, H Roman - Fertility and sterility, 2017 - Elsevier
Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical
treatment for DE can reduce symptoms but does not cure the disease, and surgical removal …

Current and emerging treatment options for endometriosis

S Ferrero, G Evangelisti, F Barra - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Pharmacotherapy has a pivotal role in the management of endometriosis with
long-term treatments balancing clinical efficacy (control of pain symptoms and prevention of …

[HTML][HTML] Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills

RF Casper - Fertility and sterility, 2017 - Elsevier
For decades, combined estrogen-progestin oral contraceptive pills (OCPs) have been the
first-line treatment for menstrual and pelvic pain associated with endometriosis without any …

Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure

FM Reis, LM Coutinho, S Vannuccini… - Human …, 2020 - academic.oup.com
BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in
general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND …

Medical treatment of endometriosis-related pain

P Vercellini, L Buggio, MP Frattaruolo, A Borghi… - Best Practice & …, 2018 - Elsevier
Available medical treatments for symptomatic endometriosis act by inhibiting ovulation,
reducing serum oestradiol levels, and suppressing uterine blood flows. For this, several …

Epigenetic dysregulation in endometriosis: implications for pathophysiology and therapeutics

RM Marquardt, DN Tran, BA Lessey… - Endocrine …, 2023 - academic.oup.com
Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …