There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by
90 genes in the human genome. Here, we present the set of 107 genes in the human …

Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated
manner with protein tyrosine kinases to control signalling pathways that underlie a broad …

Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins
and counter the activities of protein tyrosine kinases that are involved in cellular …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases, many
of which dephosphorylate threonine and tyrosine residues on mitogen-activated protein …

Polycythemia vera (PV) is a human clonal hematological disorder. The molecular etiology of
the disease has not been identified. PV hematopoietic progenitor cells exhibit …

The concerted activities of kinases and phosphatases modulate the phosphorylation levels
of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are …

Enzyme responsive materials (ERMs) are a class of stimuli responsive materials with broad
application potential in biological settings. This review highlights current and potential future …