Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …

Background: Obesity is currently viewed as a state of chronic low-grade inflammation in
which there is a pro-inflammatory alteration in the serum adipocytokine profile as well as an …

Poor microenvironmental conditions are a characteristic feature of solid tumors. Such
conditions occur because the tumor vascular supply, which develops from the normal host …

BACKGROUND AND PURPOSE: To study whether pre-therapeutic lactate or pyruvate
predict for tumour response to fractionated irradiation and to identify possible coherencies …

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to
their expression of various membrane transporter molecules (such as MDR-1), detoxifying …

Background Tumor hypoxia is associated with resistance to radiotherapy and
chemotherapy. In head and neck squamous cell carcinoma (HNSCC), nimorazole, an …

OBJECTIVE: The response of tumours to fractionated radiotherapy is determined by many
factors including repopulation, reoxygenation, the number of clonogenic cells, and their …

Purpose: In this mini-review data are summarised which provide evidence for the biological
and clinical significance of tumour glycolysis and of its relationship to the redox state of …

Despite continuous improvements in cancer management, locoregional recurrence or
metastatic spread still occurs in a high proportion of patients after radiotherapy or combined …