Salivary metabolomics: from diagnostic biomarker discovery to investigating biological function

A Gardner, G Carpenter, PW So - Metabolites, 2020 - mdpi.com
Metabolomic profiling of biofluids, eg, urine, plasma, has generated vast and ever-
increasing amounts of knowledge over the last few decades. Paradoxically, metabolomic …

Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment

G Baima, G Iaderosa, F Citterio, S Grossi, F Romano… - Metabolomics, 2021 - Springer
Introduction Early diagnosis of periodontitis by means of a rapid, accurate and non-invasive
method is highly desirable to reduce the individual and epidemiological burden of this …

Contribution of −Omics Technologies in the Study of Porphyromonas gingivalis during Periodontitis Pathogenesis: A Minireview

J Nuñez-Belmar, M Morales-Olavarria… - International journal of …, 2022 - mdpi.com
Periodontitis is a non-communicable chronic inflammatory disease characterized by the
progressive and irreversible breakdown of the soft periodontal tissues and resorption of …

Oral sources of salivary metabolites

E Hyvärinen, B Kashyap, AM Kullaa - Metabolites, 2023 - mdpi.com
The oral cavity is very diverse, wherein saliva plays an important role in maintaining oral
health. The metabolism of saliva has been used to investigate oral diseases as well as …

Assessment of changes in the oral microbiome that occur in dogs with periodontal disease

R Santibáñez, C Rodríguez-Salas, C Flores-Yáñez… - Veterinary …, 2021 - mdpi.com
The oral microbiome in dogs is a complex community. Under some circumstances, it
contributes to periodontal disease, a prevalent inflammatory disease characterized by a …

Metabolic phenotyping of saliva to identify possible biomarkers of periodontitis using proton nuclear magnetic resonance

S Kim, HJ Kim, Y Song, HA Lee, S Kim… - Journal of clinical …, 2021 - Wiley Online Library
Aim The aim of this study was to propose biomarker candidates for periodontitis via
untargeted metabolomics analysis. Materials and methods Metabolic profiling was …

Alterations and correlations in microbial community and metabolome characteristics in generalized aggressive periodontitis

M Shi, Y Wei, Y Nie, C Wang, F Sun, W Jiang… - Frontiers in …, 2020 - frontiersin.org
This study aimed to characterize the microbial community and metabolic profiles in
generalized aggressive periodontitis (AgP) using 16S ribosomal RNA (rRNA) gene high …

Saliva biomarkers in oral disease

Y Zhou, Z Liu - Clinica Chimica Acta, 2023 - Elsevier
Saliva is a versatile biofluid that contains a wide variety of biomarkers reflecting both
physiologic and pathophysiologic states. Saliva collection is noninvasive and highly …

Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water

Y Maruyama, Y Nishimoto, K Umezawa… - Scientific Reports, 2022 - nature.com
Saliva includes a substantial amount of biological information, which has enabled us to
understand the relationship between oral metabolites and various oral and systemic …

Saliva metabolomic profile in dental medicine research: a narrative review

K Tzimas, E Pappa - Metabolites, 2023 - mdpi.com
Metabolomic research tends to increase in popularity over the years, leading to the
identification of new biomarkers related to specific health disorders. Saliva is one of the most …