Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses

J Chen, F Xu, X Ruan, J Sun, Y Zhang, H Zhang… - …, 2023 - thelancet.com
Background Identifying new drug targets for inflammatory bowel disease (IBD) is urgently
needed. The proteome is a major source of therapeutic targets. We conducted a proteome …

Anti-IL23/12 agents and JAK inhibitors for inflammatory bowel disease

Z Tian, Q Zhao, X Teng - Frontiers in Immunology, 2024 - frontiersin.org
IBD (inflammatory bowel disease) is a chronic inflammatory disease of the gastrointestinal
tract with increasing incidence worldwide. Multiple factors, such as genetic background …

Inflammation-driven colorectal cancer associated with colitis: from pathogenesis to changing therapy

OM Nardone, I Zammarchi, G Santacroce, S Ghosh… - Cancers, 2023 - mdpi.com
Simple Summary Patients with inflammatory bowel disease (IBD) are at an increased risk of
developing colorectal cancer (CRC), mainly because of chronic intestinal inflammation …

ECCO guidelines on inflammatory bowel disease and malignancies

H Gordon, L Biancone, G Fiorino… - Journal of Crohn's …, 2023 - academic.oup.com
This guideline is the second European Crohn's and Colitis Organisation [ECCO] evidence-
based consensus on inflammatory bowel disease [IBD] and malignancy, and is an update …

Meta‐analysis: Real‐world effectiveness and safety of ustekinumab in patients with ulcerative colitis

C Taxonera, D Olivares… - Alimentary …, 2023 - Wiley Online Library
Background Evidence on real‐world outcomes of ustekinumab for ulcerative colitis (UC)
patients is needed. Aims To summarise evidence on the real‐world outcomes of …

Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives

Z Liu, H Liu, J Cheng, H Wang, Y Yang, J Ye… - Chinese Chemical …, 2024 - Elsevier
Ulcerative colitis (UC) is a common progressive inflammatory disease whose incidence has
increased rapidly in recent years, and can develop into colorectal cancer in severe cases …

Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease

RR Rodríguez, JJ Johnson - Pharmacology & Therapeutics, 2023 - Elsevier
Abstract Inflammatory Bowel Disease (IBD) are autoimmune diseases characterized by
chronic intestinal inflammation. Considered a western disease, IBD incidence in newly …

Extraintestinal cancers in inflammatory bowel disease: A literature review

A Massano, L Bertin, F Zingone, A Buda, P Visaggi… - Cancers, 2023 - mdpi.com
Simple Summary Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory
bowel diseases that affect the gut and extraintestinal organs. Preliminary evidence has …

Efficacy, effectiveness, and safety of Ustekinumab for the treatment of ulcerative colitis: A systematic review

JP Gisbert, E Parody-Rúa… - Inflammatory Bowel …, 2024 - academic.oup.com
Objective This study aimed to evaluate ustekinumab efficacy, effectiveness, and safety as a
treatment for ulcerative colitis in adult patients. Methods A systematic review of the efficacy …

Safety and monitoring of inflammatory bowel disease advanced therapies

S Bhat, B Click, M Regueiro - Inflammatory Bowel Diseases, 2024 - academic.oup.com
The recent approval of new medications with novel mechanisms of action and emergence of
updated safety information for existing therapies has changed the treatment landscape of …