During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that can be divided into three general stages: immediate-early (IE), early …

Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …

ABSTRACT Herpes simplex virus 1 (HSV-1) transcription is mediated by cellular RNA
polymerase II (Pol II). Recent studies investigating how Pol II transcription of host genes is …

ABSTRACT Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA
polymerase II (RNA Pol II). While four viral immediate early proteins (ICP4, ICP0, ICP27, and …

Lytic infection by herpes simplex virus 1 (HSV-1) triggers a change in many host cell
programs as the virus strives to express its own genes and replicate. Part of this process is …

CTCF is an essential chromatin regulator implicated in important nuclear processes
including in nuclear organization and transcription. Herpes Simplex Virus-1 (HSV-1) is a …

The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral
infection and affects expression of host cell genes. ICP22 is known to reduce the global level …

Herpes simplex virus type 2 (HSV-2) is a prevalent human pathogen and the main cause of
genital herpes. After initial infection, HSV-2 can establish lifelong latency within dorsal root …

Type I IFNs play an important role in innate immunity against viral infections by inducing the
expression of IFN-stimulated genes (ISGs), which encode effectors with various antiviral …

HSV-2 is the major cause of genital herpes, and its infection increases the risk of HIV-1
acquisition and transmission. After initial infection, HSV-2 can establish latency within the …