Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles
in follicle development and ovulation via a complex interaction in the hypothalamus, anterior …

Gonadotropins are glycoprotein sex hormones regulating development and reproduction
and bind to specific G protein–coupled receptors expressed in the gonads. Their effects on …

G protein-coupled receptors (GPCRs) play critical roles in transmitting a variety of
extracellular signals into the cells and regulate diverse physiological functions. Naturally …

It is well accepted that pituitary follitropin is secreted into the circulation as a mixture of
variants, which differ not in primary structure but rather at the level of glycosylation. These …

Functioning gonadotroph adenomas (FGAs) are rare tumors, as the overwhelming majority
of gonadotroph tumors are clinically silent. Literature is based on case reports and small …

STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have
greater in vivo bioactivity that drives follicle development in vivo compared to fully …

Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are
essential for reproduction. Recent studies have established that the hypo-glycosylated …

Macroheterogeneity in follicle-stimulating hormone (FSH) β-subunit N-glycosylation results
in distinct FSH glycoforms. Hypoglycosylated FSH21 is the abundant and more bioactive …

Context Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-
of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent …

It has been documented that variations in glycosylation on glycoprotein hormones, confer
distinctly different biological features to the corresponding glycoforms when multiple in vitro …