Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

The epigenetic machinery in conjunction with the transcriptional machinery is responsible
for maintaining genome-wide chromatin states and dynamically regulating gene expression …

Trimethylated histone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate
determination and differentiation. We report that a conserved bromo-adjacent homology …

We report the design and characterization of UNC3866, a potent antagonist of the
methyllysine (Kme) reading function of the Polycomb CBX and CDY families of …

Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

Chromatin-mediated processes influence the development and progression of breast
cancer. Using murine mammary carcinoma-derived tumorspheres as a functional readout for …