The development of the immunoblot to detect and characterize a protein with an antisera,
even in a crude mixture, was a breakthrough with wide-ranging and unpredictable …

The aim of this mini review is to provide an overview regarding the role of inwardly rectifying
potassium channel 4.1 (Kir4. 1)/Kir5. 1 in regulating renal K+ excretion. Deletion of Kir4. 1 in …

Chronic kidney disease (CKD) causes salt-sensitive hypertension that is often resistant to
treatment and contributes to the progression of kidney injury and cardiovascular disease. A …

Flow-induced K secretion (FIKS) in the aldosterone-sensitive distal nephron (ASDN) is
mediated by large-conductance, Ca2+/stretch-activated BK channels composed of pore …

This review highlights the molecular basis of salt sensitivity in hypertension, with a focus on
the regulation of sodium transport in the distal nephron. Sodium reabsorption in this region …

Na+ reabsorption from the distal renal tubule involves electroneutral and electrogenic
pathways, with the latter promoting K+ excretion. The relative activities of these two …

Kir4. 1/5.1 heterotetramer participates in generating the negative cell membrane potential in
distal convoluted tubule (DCT) and plays a critical role in determining the activity of Na-Cl …

Extracellular fluid (ECF) potassium concentration ([K+]) is maintained by adaptations of
kidney and skeletal muscle, responses heretofore studied separately. We aimed to …

Angiotensin II (ANG II) increases thiazide-sensitive sodium-chloride cotransporter (NCC)
activity both acutely and chronically. ANG II has been implicated as a switch that turns WNK4 …

The seminal studies conducted by Giebisch and coworkers in the 1960s paved the way for
understanding the renal mechanisms involved in K+ homeostasis. It was demonstrated that …