Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …

Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …

Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

Drugs with low water solubility are predisposed to poor and variable oral bioavailability and,
therefore, to variability in clinical response, that might be overcome through an appropriate …

As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

The current phase of drug development is witnessing an oncoming crisis due to the
combined effects of increasing R&D costs, decreasing number of new drug molecules being …

It is now just about 10 years since the publication of the first edition of Polymorphism in
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …

The physicochemical and biological properties of active pharmaceutical ingredients (APIs)
are greatly affected by their salt forms. The choice of a particular salt formulation is based on …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Salt and cocrystal formation are the most commonly used method of increasing solubility
and dissolution rate of pharmaceutical compounds, and are of particular interest for …