TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

TP53 (which encodes p53 protein) is the most frequently mutated gene among all human
cancers. Prevalent p53 missense mutations abrogate its tumour suppressive function and …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

Metastasis contributes to the vast majority of cancer-related mortality. Regulatory
mechanisms of the multistep invasion-metastasis cascade are being unraveled. TP53 is the …

In cancer, the tumour suppressor gene TP53 undergoes frequent missense mutations that
endow mutant p53 proteins with oncogenic properties. Until now, a universal mutant p53 …

Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in
the world. It is a heterogeneous disease characterized by genetic and epigenetic …

Accumulating evidences have shown that plenty of miRNAs play fundamental and important
roles in various biological processes and the deregulations of miRNAs are associated with a …