Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

Over the last decade, development and application of a set of molecular genomic
approaches based on the chromosome conformation capture method (3C), combined with …

Topologically associating domains (TADs), CTCF loop domains, and A/B compartments
have been identified as important structural and functional components of 3D chromatin …

Fit-Hi-C is a programming application to compute statistical confidence estimates for Hi-C
contact maps to identify significant chromatin contacts. By fitting a monotonically non …

The complex life cycle of Plasmodium falciparum requires coordinated gene expression
regulation to allow host cell invasion, transmission, and immune evasion. Increasing …

Underlying the development of malaria parasites within erythrocytes and the resulting
pathogenicity is a hardwired program that secures proper timing of gene transcription and …

Motivation: Recent technological advances allow the measurement, in a single Hi-C
experiment, of the frequencies of physical contacts among pairs of genomic loci at a genome …

Abstract Current three-dimensional (3D) genome modeling platforms are limited by their
inability to account for radial placement of loci in the nucleus. We present Chrom3D, a user …

The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …