[HTML][HTML] Goblet cells: multifaceted players in immunity at mucosal surfaces

KA Knoop, RD Newberry - Mucosal immunology, 2018 - Elsevier
Goblet cells (GCs) are specialized epithelial cells that line multiple mucosal surfaces and
have a well-appreciated role in barrier maintenance through the secretion of mucus …

The inflammasome in times of COVID-19

JC de Rivero Vaccari, WD Dietrich, RW Keane… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …

[HTML][HTML] NLRP3 as a potentially novel biomarker for the management of osteoarthritis

MJ McAllister, M Chemaly, AJ Eakin, DS Gibson… - Osteoarthritis and …, 2018 - Elsevier
Osteoarthritis (OA) was previously thought of as 'wear and tear'as humans age, however
there is increasing evidence to support an inflammatory theory. The nucleotide-binding and …

The Pathogenesis of Staphylococcus aureus Eye Infections

RJ O'Callaghan - Pathogens, 2018 - mdpi.com
Staphylococcus aureus is a major pathogen of the eye able to infect the tear duct, eyelid,
conjunctiva, cornea, anterior and posterior chambers, and the vitreous chamber. Of these …

Inflammasomes, the eye and anti-inflammasome therapy

P Yerramothu, AK Vijay, MDP Willcox - Eye, 2018 - nature.com
Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Reconsidering the central role of mucins in dry eye and ocular surface diseases

C Baudouin, M Rolando, JMB Del Castillo… - Progress in retinal and …, 2019 - Elsevier
Mucins are key actors in tear film quality and tear film stability. Alteration of membrane-
bound mucin expression on corneal and conjunctival epithelial cells and/or gel-forming …

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye

Q Zheng, Y Ren, PS Reinach, Y She, B Xiao… - Experimental eye …, 2014 - Elsevier
Tear film hyperosmolarity along with exposure to oxidant stress are factors that can induce
chronic ocular surface inflammation and pain. However, there is limited information on how …

DEBS–a unification theory for dry eye and blepharitis

JM Rynerson, HD Perry - Clinical Ophthalmology, 2016 - Taylor & Francis
For many years, blepharitis and dry eye disease have been thought to be two distinct
diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we …

Inflammasome: structure, biological functions, and therapeutic targets

Y Dai, J Zhou, C Shi - MedComm, 2023 - Wiley Online Library
Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

Targeting the NLRP3 inflammasome in glaucoma

S Coyle, MN Khan, M Chemaly, B Callaghan, C Doyle… - Biomolecules, 2021 - mdpi.com
Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal
ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one …