Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

Localized or topical administration of drugs may be considered as a potential approach for
overcoming the problems caused by the various biological barriers encountered in drug …

Dry eye disease (DED) is a frequently observed eye complaint, which has recently attracted
considerable research interest. Conventional therapy for DED involves the use of artificial …

Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in
part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung …

Allogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of
disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a …

Introduction: The development of ophthalmic formulations able to deliver hydrophilic and
hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has …

Exosomes contain multiple bioactive molecules and maintain the connection between cells.
Recent advances in exosome-based therapeutics have witnessed unprecedented …

Introduction: Chronic fibrotic disorders are challenging clinical problems. The major
challenge is the identification of specific targets expressed selectively in fibrotic tissues …

Calcineurin inhibitor–based graft-versus-host disease (GVHD) prophylaxis is standard in
allogeneic hematopoietic stem cell transplantation (HCT) but fails to induce long-term …

Small molecule, peptide, and protein-based drugs have been developed over decades to
treat various diseases. The importance of gene therapy as an alternative to traditional drugs …