Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Metastasis is the main cause of death in people with cancer. To colonize distant organs,
circulating tumour cells must overcome many obstacles through mechanisms that we are …

The importance of cancer-cell-autonomous functions of the tumour suppressor p53
(encoded by TP53) has been established in many studies, but it is now clear that the p53 …

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Mutations in PTEN activate the phosphoinositide 3-kinase (PI3K) signalling network, leading
to many of the characteristic phenotypic changes of cancer. However, the primary effects of …

Understanding the intricacies of lethal prostate cancer poses specific challenges due to
difficulties in accurate modeling of metastasis in vivo. Here we show that NPK EYFP mice …

A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence
pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome …

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma,
which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are …

Context Neoplastic cells are characterized by metabolic alterations that sustain tumor
growth. Interventions aimed at modifying metabolic rewiring of cancer cells are currently …