The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …

Chagas disease still has no effective treatment option for all of its phases despite being
discovered more than 100 years ago. The development of commercial drugs has been …

Chagas disease (CD)(American trypanosomiasis caused by Trypanosoma cruzi) is a
parasitic disease endemic in 21 countries in South America, with increasing global spread …

Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …

Proteases or peptidases are hydrolases that catalyze the breakdown of polypeptide chains
into smaller peptide subunits. Proteases exist in all life forms, including archaea, bacteria …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …

There are several unmet needs in modern immunology. Among them, vaccines against
parasitic diseases and chronic infections lead. Trypanosoma cruzi, the causative agent of …

Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21
Latin American countries and the southern United States and now is spreading into several …