Knee osteoarthritis (KOA) is associated with muscle weakness, but it is unclear which
structures are involved in the muscle changes. This study assessed morphological …

Motor deficits can significantly affect the completion of daily life activities and have a
negative impact on quality of life. Consequently, motor function is an important behavioral …

Behavioral assays of animal pain and disability can increase the clinical relevance of a
preclinical study. However, pain and symptoms are difficult to measure in preclinical models …

The treatment of chronic inflammation with systemically administered anti-inflammatory
treatments is associated with moderate-to-severe side effects, and the efficacy of locally …

Strategies using neural stem cells (NSCs) to aid regeneration following spinal cord injury
(SCI) show much promise, but challenges remain regarding implementation and efficacy. In …

The majority of periprosthetic joint infections occur shortly after primary joint replacement (<
3 months) and require the removal of all implant components for the treatment period (~ 4 …

In neuroscience research, the refined analysis of rodent locomotion is complex and
cumbersome, and access to the technique is limited because of the necessity for expensive …

With age, susceptibility to osteoarthritis (OA) and OA‐related pain and disability increases.
Like in OA patients, gait patterns in rodent OA models shift to protect the injured limb during …

Periprosthetic joint infections occur in about 2% of patients who undergo primary total joint
arthroplasty, a procedure performed over 1 million times in the United States. The gold …

The failure of animal studies to translate to effective clinical therapeutics has driven efforts to
identify underlying cause and develop solutions that improve the reproducibility and …