Psychological stress is a crucial factor in the development of many skin diseases, and the
stigma caused by skin disorders may further increase the psychological burden, forming a …

Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …

Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …

Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn,
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …

Itch is an aversive sensation that evokes a desire to scratch. Paradoxically, scratching the
itch also produces a hedonic experience. The specific brain circuits processing these …

Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a
phenomenon wherein the nervous system becomes hypersensitive to stimuli. This process …

Itch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent
advances in our understanding of the peripheral basis of itch, we know very little regarding …

Itch is an unpleasant sensation that elicits robust scratching and aversive experience.
However, the identity of the cells and neural circuits that organize this information remains …

Purpose Psychological stress and ensuing modulation of the immune and nervous systems
can have a significant impact on itch. Stress can exacerbate itch and vice versa, resulting in …

Clinically, it has been reported that atopic dermatitis (AD) has been linked with negative
emotional problems such as depression and anxiety, thereby reducing the quality of life, but …