The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …

Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious
effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of …

Acute graft-versus-host disease (aGVHD) is a common complication of allogeneic
hematopoietic stem cell transplantation (alloHCT) and is a major cause of morbidity and …

Acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell
transplantation (HCT) is a primary cause of nonrelapse mortality and a major barrier to …

Allogeneic hematopoietic cell transplantation (allo-HCT) can be curative in patients with
hematologic malignancies but carries a significant risk of graft-versus-host disease (GVHD) …

Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor
cells into patients with hematologic disorders with the goal of re-establishing normal …

Introduction The traditional therapeutic modalities to manage SR-acute GVHD have focused
on the inhibition of the alloreactive T-cell response, while in the setting of SR-chronic GVHD …

FoxP3+ regulatory T cells (Tregs) are a subset of CD4+ T cells that can suppress
proliferation and effector functions of T cells, B cells, NK cells, and antigen-presenting cells …

The revolutionary success of biologic agents in treating various malignant and autoimmune
conditions has been met with increased risk of opportunistic infections due to perturbations …

Background We conducted a national multicenter retrospective study in France to evaluate
the efficacy and tolerance of ruxolitinib in children with steroid‐refractory acute graft‐versus …