Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

The mammary gland develops through several distinct stages. The first transpires in the
embryo as the ectoderm forms a mammary line that resolves into placodes. Regulated by …

Synthetic progestogens (progestins) have been linked to increased breast cancer risk;
however, the role of endogenous progesterone in breast physiology and carcinogenesis is …

BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

The embryonic program 'epithelial-mesenchymal transition'(EMT) is activated during tumor
invasion in disseminating cancer cells. Characteristic to these cells is a loss of E-cadherin …

Progesterone (P) regulates female reproduction via two nuclear receptors, PR-A and PR-B.
Although both receptors display overlapping and distinct transcription regulatory properties …

Understanding the biology of the breast and how ovarian hormones impinge on it is key to
rational new approaches in breast cancer prevention and therapy. Because of the success …