Hepatitis B virus biology and life cycle
S Tsukuda, K Watashi - Antiviral research, 2020 - Elsevier
Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases.
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Q Wan, D Song, H Li, M He - Signal transduction and targeted therapy, 2020 - nature.com
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …
Pathogenicity and virulence of Hepatitis B virus
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …
an estimated 296 million people in the world that are chronically infected by this virus, and …
[HTML][HTML] Hepatitis B virus replication
J Beck, M Nassal - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
Hepadnaviruses, including human hepatitis B virus (HBV), replicate through reverse
transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to …
transcription of an RNA intermediate, the pregenomic RNA (pgRNA). Despite this kinship to …
Hepatitis B viruses: reverse transcription a different way
M Nassal - Virus research, 2008 - Elsevier
Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is the type
member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse …
member of the Hepadnaviridae, hepatotropic DNA viruses that replicate via reverse …
The Hsp90 molecular chaperone: an open and shut case for treatment
The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile
protein involved in the stress response and in normal homoeostatic control mechanisms. It …
protein involved in the stress response and in normal homoeostatic control mechanisms. It …
[HTML][HTML] Hepatitis B virus morphogenesis
V Bruss - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
The hepatitis B virus (HBV) particle consists of an envelope containing three related surface
proteins and probably lipid and an icosahedral nucleocapsid of approximately 30 nm …
proteins and probably lipid and an icosahedral nucleocapsid of approximately 30 nm …
[HTML][HTML] Broad action of Hsp90 as a host chaperone required for viral replication
Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …
Secretion of genome-free hepatitis B virus–single strand blocking model for virion morphogenesis of para-retrovirus
X Ning, D Nguyen, L Mentzer, C Adams, H Lee… - PLoS …, 2011 - journals.plos.org
As a para-retrovirus, hepatitis B virus (HBV) is an enveloped virus with a double-stranded
(DS) DNA genome that is replicated by reverse transcription of an RNA intermediate, the …
(DS) DNA genome that is replicated by reverse transcription of an RNA intermediate, the …
Development of direct-acting antiviral and host-targeting agents for treatment of hepatitis B virus infection
Hepatitis B virus (HBV) infection affects approximately 300 million people worldwide.
Although antiviral therapies have improved the long-term outcomes, patients often require …
Although antiviral therapies have improved the long-term outcomes, patients often require …