Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant
and pan-drug resistant pathogens which are associated with considerable mortality …

Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused
predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs …

Artemisinin-based combination treatments (ACTs) are now generally accepted as the best
treatments for uncomplicated falciparum malaria. They are rapidly and reliably effective …