The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

The field of hereditary kidney cancer has begun to mature following the identification of
several germline syndromes that define genetic and molecular features of this cancer …

Cell-based therapy is a promising strategy in regenerative medicine, but the poor survival
rate of the implanted cells remains a major challenge and limits clinical translation. We …

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of
which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the …

The presence of hypoxic regions in solid tumors is an adverse prognostic factor for patient
outcome. Here, we show that hypoxia induces the expression of Ephrin-A3 through a novel …

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …

Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial
factor in the initiation and maintenance of alcohol use disorder (AUD). However, the …

Background Metastasis is responsible for a significant number of breast cancer-related
deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of …

We analyzed the effects of selective knockdown of either HIF-1α or HIF-2α on the
transcriptional response to hypoxia of human umbilical endothelial cells at two time-points (2 …

Cells adapt to environmental changes, including fluctuations in oxygen levels, through the
induction of specific gene expression programs. To identify genes regulated by hypoxia at …