The unsolved enigmas of leukemia inhibitory factor

D Metcalf - Stem cells, 2003 - academic.oup.com
Leukemia inhibitory factor (LIF) is a polyfunctional glycoprotein cytokine whose inducible
production can occur in many, perhaps all, tissues. LIF acts on responding cells by binding …

Genetics of early mammalian folliculogenesis

Y Choi, A Rajkovic - Cellular and molecular life sciences, 2006 - Springer
Early ovarian folliculogenesis begins with the breakdown of germ cell clusters and formation
of primordial follicles. Primordial follicles are the smallest ovarian follicle units continuously …

Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis

R Shkhyan, C Flynn, E Lamoure, A Sarkar… - Science translational …, 2023 - science.org
Adult mammals are incapable of multitissue regeneration, and augmentation of this potential
may shift current therapeutic paradigms. We found that a common co-receptor of interleukin …

Current knowledge of IL-6 cytokine family members in acute and chronic kidney disease

AL Magno, LY Herat, R Carnagarin, MP Schlaich… - Biomedicines, 2019 - mdpi.com
Healthy kidneys are important for the efficient regulation of metabolism. However, there is an
ever increasing population of patients suffering from both acute and chronic kidney diseases …

Leukemia inhibitory factor promotes castration-resistant prostate cancer and neuroendocrine differentiation by activated ZBTB46

YN Liu, S Niu, WY Chen, Q Zhang, Y Tao… - Clinical Cancer …, 2019 - AACR
Purpose: The molecular targets for castration-resistant prostate cancer (CRPC) are unknown
because the disease inevitably recurs, and therapeutic approaches for patients with CRPC …

Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure

J Yoshino, T Monkawa, M Tsuji… - Journal of the …, 2003 - journals.lww.com
Leukemia inhibitory factor (LIF) is known to play a crucial role in the conversion of
mesenchyme into epithelium during nephrogenesis. This study was carried out to test the …

Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease

N Perretta‐Tejedor, KL Price, DJ Jafree… - Physiological …, 2024 - Wiley Online Library
Abstract Cardiotrophin‐1 (CT‐1), a member of the interleukin (IL)‐6 cytokine family, has
renoprotective effects in mouse models of acute kidney disease and tubulointerstitial …

Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c

Y Yu, Y Wang, Y Niu, L Fu… - American Journal of …, 2015 - journals.physiology.org
Leukemia inhibitory factory (LIF), as a member of the IL-6 family, has been reported to
ameliorate myocardial fibrosis and myocardial cell death. The purpose of the present study …

Leukemia inhibitory factor: A main controller of breast cancer

N Vaziri, L Shariati, SH Javanmard - Journal of biosciences, 2020 - Springer
Breast cancer is the second leading cause of cancer-related death among females,
worldwide. The cytokines are proteins that have a significant role in the development of …

[HTML][HTML] Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio)

PC Hanington, SA Patten, LM Reaume… - Developmental …, 2008 - Elsevier
Leukemia inhibitory factor (LIF) is a member of the IL-6 cytokine family that functions in the
survival, repair and formation of neurons as well as in the maintenance of neural and …