HIV tissue reservoirs: current advances in research

K Li, B Liu, R Ma, Q Zhang - AIDS patient care and STDs, 2023 - liebertpub.com
Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …

Immunocompetent human 3D organ-specific hormone-responding vaginal mucosa model of HIV-1 infection

I Saba, C Barat, S Chabaud, N Reyjon… - … Engineering Part C …, 2021 - liebertpub.com
The lack of appropriate experimental models often limits our ability to investigate the
establishment of infections in specific tissues. To reproduce the structural and spatial …

Ex-vivo rectal tissue infection with HIV-1 to assess time to protection following oral preexposure prophylaxis with tenofovir disoproxil/emtricitabine

S Chawki, L Goldwirt, M El Mouhebb, A Gabassi… - AIDS, 2024 - journals.lww.com
Objectives: We wished to assess time to protection from HIV-1 infection following oral
tenofovir disoproxil and emtricitabine (TDF/FTC) as preexposure prophylaxis (PrEP), using …

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides

I Rodríguez‐Izquierdo… - Wiley …, 2022 - Wiley Online Library
Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy,
most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 …

The use of droplet digital PCR to quantify HIV-1 replication in the colorectal explant model

A Myerski, A Siegel, J Engstrom… - AIDS research and …, 2019 - liebertpub.com
Ex vivo explant models are used to characterize in vitro efficacy of preexposure prophylaxis
(PrEP) agents. Tissue is challenged with virus in culture and HIV-1 p24 levels are quantified …

Assessment of different post-exposure prophylaxis regimens for prevention of HIV infection in exposed individuals

A Inciarte Portillo - 2023 - diposit.ub.edu
[eng]• PEP completion rates for sexual assault victims will be lower compared to other
individuals for whom PEP is prescribed.• TDF/FTC+ EVG/c, as a once-daily single tablet …