Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

The complexity of the human brain has made it difficult to study many brain disorders in
model organisms, highlighting the need for an in vitro model of human brain development …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that
is characterised by microcephaly present at birth and non-progressive mental retardation …

Centrioles are microtubule-derived structures that are essential for the formation of
centrosomes, cilia and flagella. The centrosome is the major microtubule organiser in animal …

Preservation of genome integrity via the DNA-damage response is critical to prevent
disease. ATR (ataxia telangiectasia mutated-and Rad3-related) is essential for life and …

A mutation in the centrosomal‐P4. 1‐associated protein (CPAP) causes Seckel syndrome
with microcephaly, which is suggested to arise from a decline in neural progenitor cells …

Context: Genetics plays a major role in determining an individual's height. Although there
are many monogenic disorders that lead to perturbations in growth and result in short …

Meier-Gorlin syndrome (ear, patella and short-stature syndrome) is an autosomal recessive
primordial dwarfism syndrome characterized by absent or hypoplastic patellae and markedly …