This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Prodrugs are derivatives with superior properties compared with the parent active
pharmaceutical ingredient (API), which undergo biotransformation after administration to …

Valacyclovir is the l-valyl ester prodrug of the antiviral drug acyclovir that exhibits activity
against Herpes simplex virus types and varicella zoster virus. An explicit surface analysis on …

Introduction: The molecular revolution greatly impacted the field of drug design and delivery
in general, and the utilization of the prodrug approach in particular. The increasing …

Undesirable taste is an important problem for patient compliance. Several oral
pharmaceuticals and bulking agents have disagreeable and bitter-tasting components. The …

DFT calculations for the acid-catalyzed hydrolysis of several maleamic acid amide
derivatives revealed that the reaction rate-limiting step is determined on the nature of the …

Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

The palatability of the active ingredient of a drug is a significant obstacle in developing a
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …

Prodrugs are designed to improve pharmaceutical/biopharmaceutical characteristics,
pharmacokinetic/pharmacodynamic properties, site-specificity, and more. A crucial step in …

Resistance against clinically approved anticancer drugs is the main roadblock in cancer
treatment. Drug metabolizing enzymes (DMEs) that are capable of metabolizing a variety of …