Clinical applications of metabolomics in oncology: a review

JL Spratlin, NJ Serkova, SG Eckhardt - Clinical cancer research, 2009 - AACR
Metabolomics, an omic science in systems biology, is the global quantitative assessment of
endogenous metabolites within a biological system. Either individually or grouped as a …

Metabolomics-based methods for early disease diagnostics

GAN Gowda, S Zhang, H Gu, V Asiago… - Expert review of …, 2008 - Taylor & Francis
The emerging field of metabolomics, in which a large number of small-molecule metabolites
from body fluids or tissues are detected quantitatively in a single step, promises immense …

Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

K Sonkar, V Ayyappan, CM Tressler… - NMR in …, 2019 - Wiley Online Library
Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

In vivo detection of apoptosis

FG Blankenberg - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
After several decades of debate, it is now widely acknowledged that apoptosis, also known
as programmed cell death, is central to homoeostasis and normal development and …

MR‐visible lipids and the tumor microenvironment

EJ Delikatny, S Chawla, DJ Leung… - NMR in …, 2011 - Wiley Online Library
MR‐visible lipids or mobile lipids are defined as lipids that are observable using proton MRS
in cells and tissues. These MR‐visible lipids are composed of triglycerides and cholesterol …

Metabolomics: moving to the clinic

A Nordström, R Lewensohn - Journal of Neuroimmune Pharmacology, 2010 - Springer
Assessment of a biological system by means of global and non-targeted metabolite profiling—
metabolomics or metabonomics—provides the investigator with molecular information that is …

Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics

GF Giskeødegård, MT Grinde, B Sitter… - Journal of proteome …, 2010 - ACS Publications
Axillary lymph node status together with estrogen and progesterone receptor status are
important prognostic factors in breast cancer. In this study, the potential of using MR …

Merging transcriptomics and metabolomics-advances in breast cancer profiling

E Borgan, B Sitter, OC Lingjærde, H Johnsen… - BMC cancer, 2010 - Springer
Background Combining gene expression microarrays and high resolution magic angle
spinning magnetic resonance spectroscopy (HR MAS MRS) of the same tissue samples …

HR MAS MR spectroscopy in metabolic characterization of cancer

S Moestue, B Sitter, T Frost Bathen… - Current topics in …, 2011 - ingentaconnect.com
One of the central hallmarks of cancer is the rapid and infinite cellular proliferation. In order
to cope with increased requirement for building blocks and energy, cancer cells develop …

Metabolomics of cancer

NJ Serkova, K Glunde - Tumor Biomarker Discovery: Methods and …, 2009 - Springer
Metabolomics, one of the “omic” sciences in systems biology, is the global assessment and
validation of endogenous small-molecule biochemicals (metabolites) within a biologic …