Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Breast cancer accounts for 25% of the cancers in women worldwide. The most common
subtype of breast cancer diagnosed is hormone receptor positive, which expresses the …

Background Breast cancer brain metastases (BrMs) are defined by complex adaptations to
both adjuvant treatment regimens and the brain microenvironment. Consequences of these …

Around 70–85% of all breast cancer (BC) cases are estrogen receptor-positive (ER+). The
third generation of aromatase inhibitors (AIs) is the first-line treatment option for these …

Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial
roles on a spectrum of developmental and physiological processes. The biological actions of …

Abstract Estrogen receptor-positive (ER+) breast carcinomas are the most common subtype,
corresponding to 60% of the cases in premenopausal and 75% in postmenopausal women …

Abstract Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other
transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes …

Background Endocrine therapy resistance is a hallmark of advanced estrogen receptor (ER)-
positive breast cancer. In this study, we aimed to determine acquired genomic changes in …

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to
orchestrate transcriptional networks to drive disease progression. In primary breast cancer …

Venous malformation (VM) and cavernous venous malformation (CVM) are two types of
vascular malformations. Even if the two diseases are similar in appearance and imaging, the …