Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper
distribution of potassium across the cell membrane is critical for normal cell function. Long …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Euryhaline teleosts exhibit major changes in renal function as they move between
freshwater (FW) and seawater (SW) environments, thus tolerating large fluctuations in …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Introduction: Piperazine, a six membered nitrogen containing heterocycle, is of great
significance to the rational design of drugs. This moiety can be found in a plethora of well …

Maintenance of extracellular K+ concentration within a narrow range is vital for numerous
cell functions, particularly electrical excitability of heart and muscle. Potassium homeostasis …

Potassium homeostasis has a very high priority because of its importance for membrane
potential. Although extracellular K+ is only 2% of total body K+, our physiology was …

The Kir3. 1 K+ channel participates in heart rate control and neuronal excitability through G‐
protein and lipid signaling pathways. Expression in Escherichia coli has been achieved by …

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium
channel (Kir), Kcnj10 (Kir4. 1), includes salt wasting, hypomagnesemia, metabolic alkalosis …