RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-
dependent kinases. However, many proteins that control DNA replication, RNA transcription …

DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short
double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains …

DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the
yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to …

More than half of the~ 20,000 protein-encoding human genes have paralogs. Chemical
proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to …

DEAD/H box helicases are implicated in lung cancer but have not been systematically
investigated for their clinical significance and function. In this study, we aimed to evaluate …

In the era of advancement, the entire world continues to remain baffled by the increased rate
of progression of cancer. There has been an unending search for novel therapeutic targets …

Proteins are the workhorse molecules performing various tasks to sustain life. To investigate
the roles of a protein under physiological conditions, the rapid modulation of the protein with …

More than half of the~ 20,000 protein-encoding human genes have at least one paralog.
Chemical proteomics has uncovered many electrophile-sensitive cysteines that are …

RNA helicases represent attractive drug targets as their activity is linked to several human
diseases and impacts microbial infectious processes. While some inhibitors of human RNA …