Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex
pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a …

Venous thrombosis (VT), a leading cause of morbidity and mortality worldwide, has recently
been linked to neutrophil activation and release of neutrophil extracellular traps (NETs) via a …

Although improving, the mortality from septic shock still remains high despite increased
international awareness. As a consequence, much effort has focused on alternative …

The existence of extracellular DNA in human plasma, also known as cell‐free DNA (cf DNA),
was first described in the 1940s. In recent years, there has been a resurgence of interest in …

Systemic inflammation-associated syndromes (eg, sepsis and septic shock) often have high
mortality and remain a challenge in emergency medicine. Systemic inflammation is usually …

Background Although severe sepsis constitutes an important burden for healthcare systems,
there is limited nationwide data on its epidemiology in European countries. Our objective …

Background: Patients with sepsis commonly exhibit a hypercoagulability with high risk of
venous thromboembolism (VTE). Neutrophil extracellular traps (NETs) are found to trigger …

Background. Aging-related changes in platelet and monocyte interactions may contribute to
adverse outcomes in sepsis but remain relatively unexamined. We hypothesized that …

Background There is an increase in admission rate for elderly patients to the ICU. Mortality
rates are lower when more liberal ICU admission threshold are compared to more restrictive …