[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Microglia regulate central nervous system myelin growth and integrity

NB McNamara, DAD Munro, N Bestard-Cuche… - Nature, 2023 - nature.com
Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …

Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

JWE Moss, DP Ramji - Future medicinal chemistry, 2016 - Taylor & Francis
Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic
inflammatory disorder in the walls of medium and large arteries. CVD is currently …

Role of TGFβ signaling in the pathogenesis of Alzheimer's disease

R Von Bernhardi, F Cornejo, GE Parada… - Frontiers in cellular …, 2015 - frontiersin.org
Aging is the main risk factor for Alzheimer's disease (AD); being associated with
conspicuous changes on microglia activation. Aged microglia exhibit an increased …

[HTML][HTML] The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis

ML Buckley, DP Ramji - Biochimica et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
Atherosclerosis, the underlying cause of myocardial infarction and thrombotic
cerebrovascular events, is responsible for the majority of deaths in westernized societies …

Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension

NY Chen, S D. Collum, F Luo, T Weng… - … of Physiology-Lung …, 2016 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. The
development of pulmonary hypertension (PH) is considered the single most significant …

[HTML][HTML] Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis

H Gallagher, JO Williams, N Ferekidis, A Ismail… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Atherosclerosis and its complications are responsible for one in three global deaths.
Nutraceuticals show promise in the prevention and treatment of atherosclerosis but require …

Phenotypic Modulation of Macrophages and Vascular Smooth Muscle Cells in Atherosclerosis—Nitro-Redox Interconnections

J Bonetti, A Corti, L Lerouge, A Pompella, C Gaucher - Antioxidants, 2021 - mdpi.com
Monocytes/macrophages and vascular smooth muscle cells (vSMCs) are the main cell types
implicated in atherosclerosis development, and unlike other mature cell types, both retain a …

The diverse roles of macrophages in metabolic inflammation and its resolution

A Guha Ray, OP Odum, D Wiseman… - Frontiers in Cell and …, 2023 - frontiersin.org
Macrophages are one of the most functionally diverse immune cells, indispensable to
maintain tissue integrity and metabolic health. Macrophages perform a myriad of functions …

[HTML][HTML] Regulation of ADAMTS-1,-4 and-5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel …

TG Ashlin, APL Kwan, DP Ramji - Cytokine, 2013 - Elsevier
Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines.
Macrophages play a crucial role at all stages of this disease, including regulation of foam …