A review on the protective effects of naringenin against natural and chemical toxic agents

K Naraki, R Rezaee, G Karimi - Phytotherapy Research, 2021 - Wiley Online Library
Naringenin (NRG), as a flavanone from flavonoids family, is widely found in grapefruit,
lemon tomato, and Citrus fruits. NRG has shown strong anti‐inflammatory and antioxidant …

Guidance for the use and interpretation of assays for monitoring anti-genotoxicity

V Yadav, JL Fuentes, A Krishnan, N Singh, D Vohora - Life Sciences, 2024 - Elsevier
Since DNA damage can occur spontaneously or be produced by the environmental
genotoxins in living cells, it is important to investigate compounds that can reverse or protect …

Vitamin E protects against cisplatin-induced genotoxicity in human lymphocytes

LN Al-Eitan, KH Alzoubi, LI Al-Smadi, OF Khabour - Toxicology In Vitro, 2020 - Elsevier
Cisplatin is an anticancer drug that is widely used in treatments of human malignancies such
as ovaries,'testes,'and solid tumors of the head and neck. However, the use of cisplatin in the …

Evaluation of toxicity and mutagenicity of oxaliplatin on germ cells in an alternative in vivo model Caenorhabditis elegans

Y Feng, Z Cao, A Xu, H Du - Food and Chemical Toxicology, 2023 - Elsevier
The platinum compound oxaliplatin is a widely used chemotherapeutic drug that shows a
broad spectrum of activity in various human tumors. While the treatment-related side effects …

Vitamin E modifies high-fat diet-induced reduction of seizure threshold in rats: Role of oxidative stress

KH Alzoubi, ZA Hasan, OF Khabour, FA Mayyas… - Physiology & …, 2019 - Elsevier
There is increasing evidence that oxidative stress is a causal factor in different
neurodegenerative disorders such as Alzheimer's disease and epilepsy. High-fat diet (HFD) …

In vitro genotoxicity assessment of functional ingredients: DHA, rutin and α-tocopherol

J Sanz-Serrano, A Vettorazzi, D Muruzabal… - Food and chemical …, 2021 - Elsevier
The in vitro genotoxicity of three compounds widely used as functional ingredients,
docosahexaenoic acid (DHA), rutin and α-tocopherol, was assessed. A miniaturized version …

[HTML][HTML] Cilostazol geno-protective effects mitigate carbamazepine-induced genotoxicity in human cultured blood lymphocytes

EM Al Momany, AM Rababa'h, KH Alzoubi… - Toxicology Reports, 2024 - Elsevier
Background Carbamazepine is one of the most widely used antiepileptic drugs.
Carbamazepine has been shown to be toxic to cells. Cilostazol, an antiplatelet agent, has …

Vitamin E prevents the cognitive impairments in post-traumatic stress disorder rat model: behavioral and molecular study

M Ahmed, KH Alzoubi, OF Khabour - Psychopharmacology, 2020 - Springer
Rationale Post-traumatic stress disorder (PTSD) is a psychiatric disorder developed after an
exposure to severe traumatic events. Patients with PTSD suffer from different symptoms …

[HTML][HTML] Vitamin B12 protects against DNA damage induced by hydrochlorothiazide

KH Alzoubi, E Bayraktar, O Khabour… - Saudi Pharmaceutical …, 2018 - Elsevier
DNA damage induced by hydrochlorothiazide was previously reported in cultured human
lymphocytes. In this study, we aimed to investigate the harmful effects of hydrochlorothiazide …

[HTML][HTML] Evaluation of mutagenic activity of platinum complexes in somatic cells of Drosophila melanogaster

N Allgayer, RA de Campos, LPF Gonzalez… - Food and Chemical …, 2019 - Elsevier
Cisplatin, carboplatin, and oxaliplatin are some of the most often used alkylating
chemotherapeutic agents. In view of the paucity of data on the genotoxicity of oxaliplatin, this …